The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may well end in a rise in methadone plasma concentrations, which could induce potentially fatal respiratory despair. In addition, discontinuation of concomitantly utilised cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers might also end in a rise in meth